Transient global amnesia statins12/20/2023 ![]() ![]() Tirzepatide (Mounjaro) as well as semaglutide may be able to keep pre-diabetes like yours from becoming Type 2 diabetes. Bariatric surgery or restricted diets can lead to telogen effluvium, in which many follicles let go of their hairs. You might well be right that the hair loss some people report with semaglutide (Ozempic, Wegovy) is due to rapid weight loss. In addition, I really haven’t had much hair loss.Ī. I have lost less than 20 pounds so far, but my blood glucose numbers improved dramatically. The doctor wanted to put me on Ozempic, and I asked to try Mounjaro because I’ve heard it’s stronger. I had cut out fast food, but my weight was increasing again no matter what I tried. My doctor diagnosed me with insulin resistance and said I was headed for Type 2 diabetes. I’ve been taking Mounjaro for six months. Is that an actual side effect of the medication or a result of losing a lot of weight very quickly? Some years back, I tried a severely restricted diet and lost quite a bit of hair. You’ve written that Ozempic and Wegovy can cause hair loss. That said, the Food and Drug Administration requires this notification in the official prescribing information: “There have been rare reports of cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion) associated with the use of all statins.” There are relatively few reports of TGA associated with statins in the medical literature. He wrote about this topic in his book “Lipitor, Thief of Memory.” Graveline was convinced that his amnesia episodes were triggered by atorvastatin. Six weeks later, he had a 12-hour episode of TGA, during which he forgot that he was a doctor and could not remember his wife’s name.ĭr. He stopped taking Lipitor but was encouraged to restart the drug a year later after his annual physical. ![]() A complete medical workup showed no neurological problems. Six weeks after starting Lipitor, he experienced a six-hour episode of TGA. He was a former astronaut and a retired family physician. We first heard about transient global amnesia from Dr. The TGA episodes were more frightening than all the other side effects combined.Ī. Then I developed Type 2 diabetes, peripheral neuropathy, reduced kidney function and transient global amnesia. ![]() My kidney function was also good for my age.Įverything was great for several years. I was on no other medication and my blood sugar count was normal. My doctor prescribed Lipitor when it was a hot drug for lowering cholesterol. These considerations permit the construction of a hypothesis of TGA pathogenesis which may have testable, falsifiable, predictions.Īttractor network Hypothesis Pathophysiology Spreading depolarization Transient global amnesia.Ĭopyright © 2022 Elsevier Ltd. ![]() At the mechanistic level, spreading depolarization is suggested to underpin these changes. In terms of the energy landscape, the system flips to a shallower, low firing rate, basin of attraction. Excessive positive feedback through the CA3 recurrent collaterals produces runaway neural firing, with infinite gain in the short CA3 feedback loops, resulting in a singularity or discontinuity manifest as failure of synaptic transmission. Based on the intrinsic neuronal circuitry of the hippocampal formation, specifically the rich CA3 recurrent collateral projections which have previously been characterised as a global autoassociative attractor network, a model of TGA is developed in which loss of fault tolerance, a property of attractor networks, results in catastrophic rather than graceful degradation. Based on a computational neural network model of mnemonic function, a new model of TGA pathogenesis is suggested, along with potential mechanisms, thus generating a potentially testable hypothesis of TGA pathogenesis. Existing proposals - epileptic seizure, stroke or transient ischaemic attack, migraine aura - all have shortcomings. Although the clinical phenomenology, neuropsychology, neuroimaging, prognosis, and precipitating and predisposing factors of TGA are well described, the pathogenesis is not currently understood. Transient global amnesia (TGA) is a rare but well-described neurological disorder characterised by an acute self-limited episode of dense anterograde amnesia with retrograde amnesia of variable extent. ![]()
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